Lawson Laboratory



There are a number of different forces that act upon the blood vessel wall. There is the laminar shear stress of red blood cells (and other components of the blood) that generates tangential force. There is also perpendicular force and the resultant stretch that comes with the pressure generated with each heartbeat. How endothelial cells respond at the molecular and cellular level to these forces is an area of great interest as perturbation of this response can contribute to atherosclerosis. We have recently begun to apply the many benefits of the zebrafish to investigate the effect of blood flow on endothelial cells in vivo during development.
Hemodynamic control of angiogenesis