Lawson Laboratory



To study the effect of flow on blood vessel morphogenesis, we have focused on the development of the aortic arches. These vessels remodel extensively in all vertebrates and must do so in the presence of active circulation. In the zebrafish, aortic arches 5 and 6 (aa5 and aa6) initially form as blind ended sprouts emanating from the ventral aorta (VA). These sprouts subsequently grow by angiogenesis and fuse to the lateral branches of the dorsal aorta (LDA) to feed the trunk vascular network. The aortic arches continue to grow (presumably via angiogenesis) throughout the larval period and will become the major site for gas exchange.
Hemodynamic control of angiogenesis: the aortic arches